ZUMBRUNN, JURG,DEMARCO, STEVEN J.,MUKHERJEE, RESHMI,MOEHLE, KERSTIN,ROBINSON, JOHN ANTHONY,HENZE, HEIKO,ROMAGNOLI, BARBARA,LOCIURO, SERGIO,VRIJBLOED, JAN WIM,GOMBERT, FRANK,OBRECHT, DANIEL,LUDIN, CHRI
申请号：
CA2847486
公开号：
CA2847486C
申请日:
2004.04.29
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Template-fixed .beta.-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 .alpha.-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients； or where cancer is mediated or resulting from CXCR4 receptor activity； or where immunological diseases are mediated or resulting from CXCR4 receptor activity； or for treating immuno suppression； or during apheresis collections of peripheral blood stem cells. These .beta.-hairpin peptidornimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
