The present invention provides a prevention and/or therapeutic agent for Trk-associated diseases and, in addition to having Trk selective inhibitory activity, persistently inhibiting NGF vascular hyperpermeability, and no drug interactions, it is a compound having excellent solubility and absorption with respect to the free base.The compound of present invention has Trk selective inhibitory activity, persistently inhibiting NGF vascular hyperpermeability, no drug interactions, and it is a compound having excellent solubility and absorption with respect to the free base, hence it can serve as a prevention and/or therapeutic drugs for Trk-associated diseases.本發明係為了提供Trk關連疾病之預防及/或治療劑，而提供除了具有Trk選擇性阻礙活性、持續性抑制NGF血管透過性亢進、且未具有藥物交互作用之外，更對於遊離鹼之溶解性、吸收性優越之化合物。本發明化合物為具有Trk選擇性阻礙活性、持續性抑制NGF血管透過性亢進、未具有藥物交互作用，對於遊離鹼之溶解性、吸收性優越之化合物，作為Trk關連疾病之預防及/或治療藥有用。
