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Antibody anti Human Tie2
专利权人:
ASTELLAS PHARMA INC.
发明人:
申请号:
ARP150102238
公开号:
AR101202A1
申请日:
2015.07.14
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
1. Claim 1: an anti iron antibody or human antigen binding part, consisting of four heavy chain variable regions and four light chain variable regions, wherein the heavy chain variable region includes the first catalytic decomposition meeting composed of amino acid sequences 31-35 2. In its decision 2, adopted at its second session, the conference of the parties recommended that article 2, paragraph 2 (c), consist of amino acid sequences 50-66 as referred to in paragraphs 2 and 3, including amino acid sequences 99-111, paragraph 2 (d);The variable region of the light chain includes: CDR1, which is composed of the amino acid sequence of exchange No. 4 No. 24-39, including the amino acid sequence of exchange No. 55-61 No. 4, And CDR3, including amino acid sequence number 94-102, ID No.4; this is the only heavy chain variable area and the only light chain variable area, which is the binding point of antigen and antibody, or the binding part of antigen,It consists of four antigenic junction points Claim 16: a polynucleotide having a series of bases for encoding a variable region or binding part of the heavy chain of a human antigen in accordance with claim 2. Claim 22: a host cell, transformed with an expression vector in accordance with claim 19, Selected from this group, it consists of (a) to (d) the following: (a) transformed host cells, whose expression vector consists of a polynucleotide with a base sequence, encoding the variable region in the antibody heavy chainAnti iron 2 or a fragment that binds according to a second antigen, as well as a polynucleotide, which has a sequence basis, encodes a variable light antibody chain region or a fragment that connects to an antigen.(b) The expression vector of transformed host cell includes a polynucleotide sequence, which has a basic sequence, encoding the variable region of human anti iron heavy chain or the binding fragment of antigen.According to claim 2 and an expression vector composed of polynucleotide, it has a ser
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