Decellularized and shaped corneal tissue lenticules from allograft and/or xenograft sources and methods of obtaining such lenticules are disclosed. The lenticules are particularly useful as intrastromal lenticular implants in keratoplasty procedures, in which a hinged flap is formed in a patients cornea and folded back along its hinge to expose the stromal bed of the cornea. The shaped lenticule is then applied to the stromal bed and the flap returned to its original position yielding a new curvature for the cornea and resulting in a desired refractive correction. Fine-tuning of the new refractive power can be achieved by laser ablation either at the same time as implantation or at later time in the event of regression or tonus changes. Methods of decellularizing cornea tissue are disclosed to reduce potential immunogenic reactions on the part of the patient to the implanted lenticule. The lenticules can be further treated to remove immunogenic epitopes. In addition, the posterior and/or anterior surfaces of the lenticule can be treated to assist in intrastromal seating of the lenticule and/or to reduce the likelihood of dislodgement. The methods of forming lenticules can further include preserving at least a portion of the Bowmans membrane. The smoothness of the Bowmans membrane surface also makes it less likely that reopening the flap will dislodge the lenticule.La présente invention concerne des lenticules de tissu cornéen décellularisé et formé provenant de sources dallogreffe et/ou de xénogreffe et des procédés dobtention de tels lentilcules. Les lenticules sont particulièrement utiles en tant quimplants lenticulaires intrastromaux dans des procédures de kératoplastie, dans lesquelles un lambeau articulé est formé dans la cornée dun patient et replié le long de sa charnière pour exposer le lit stromal de la cornée. Le lenticule formé est ensuite appliqué sur le lit de stroma et le lambeau est retourné à sa position dorigine, de façon à produire une nouvelle cou
