Systems and methods for mitigating or preventing opioid overdoses are disclosed herein. More specifically, an overdose mitigation system includes an overdose sensor, such as a pulse oximeter, that is strapped around a users arm in a similar manner as a blood pressure cuff. The system measures an overdose indicator, such as a minimum oxygen saturation level. When the indicator is detected, the system sounds an alarm and automatically injects an opioid antidote (e.g., intramuscularly), via an attached injector with a reservoir containing the antidote, unless an input is received from a user interface. Thus, systems and methods disclosed herein allow for an antidote to be automatically delivered to a user at risk of death from overdose, without having to wait on a first responder or rely on a caregiver.
