The present invention relates to compositions and methods for modulating the Wnt signaling pathway, having Formula (1) or (2):wherein R1, R2, R3, A1, A2, X1, X2, X3, X4, Y and Z are as defined above.本發明係關於一種調控Wnt訊號傳導路徑之組合物及方法,其具有式(1)或(2):其中R1、R2、R3、A1、A2、X1、X2、X3、X4、Y及Z係如本文中所定義。