USO DE ANTICUERPOS ANTI-CGRP Y FRAGMENTOS DE ANTICUERPO PARA PREVENIR O INHIBIR LA FOTOFOBIA O AVERSION A LA LUZ EN SUJETOS EN NECESIDAD DE LOS MISMOS, ESPECIALMENTE PACIENTES CON MIGRAÑA.
BRIAN ROBERT KOVACEVICH,LEON F. GARCIA-MARTINEZ,JOHN A. LATHAM,ANDREW F. RUSSO,ERIC A. KAISER,ANA RECOBER,ADISA KUBURAS,ANN C. RADDANT,JEFFREY T.L. SMITH
申请号：
MX2013013533
公开号：
MX2013013533A
申请日:
2012.05.21
申请国别(地区):
MX
年份:
2014
代理人:
摘要：
The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like. The present invention also provides assays using transgenic Nestin/Ramp1 rodents, utilizing a CGRP model light aversive behavior model for identifying therapeutically effective anti-CGRP antibodies and fragments thereof having binding specificity for CGRP which inhibit or prevent photophobia in subjects in need thereof. The present invention is specifically directed to methods for identifying therapeutically effective antibodies and fragments thereof having binding specificity for CGRP that may be used to treat CGRP associated disorders such as migraine. Specifically, this invention relates to assays and therapies using the antibodies described herein to inhibit or prevent photophobia, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them.La presente invención se dirige a métodos para inhibir o prevenir la fotofobia en sujetos en necesidad de los mismos usando anticuerpos anti-CGRP o fragmentos de anticuerpo que inhiben la fotofobia, especialmente la fotofobia asociada con CGRP. Estos anticuerpos y fragmentos son útiles en tratar diferentes trastornos asociados con la fotofobia tales como migraña, dolores de cabeza por multitud y los similares. La presente invención también proporciona ensayos usando roedores Nestin/Rampl transgénicos, utilizando un modelo de comportamiento aversivo a la luz de modelo CGRP para identificar anticuerpos anti-CGRP terapéuticamente efectivos y fragmentos de los mismos que tienen especificidad de enlace para CGRP que inhiben o previenen la fotofobia en sujetos en necesidad
