Research Institute at Nationwide Children's Hospital
发明人:
Christopher Breuer,Narutoshi Hibino,Vidu Garg,Cameron Best
申请号：
US15308445
公开号：
US20170073401A1
申请日:
2015.05.04
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Excessive or repeated activation of inflammatory and pro-coagulant mechanisms at the site of tissue injury contributes to the development scar tissue that can lead to intimal hyperplasia and fibrotic disease. It has been established that inhibition of the LYST protein is associated with reduced inflammatory responses and reduced platelet activation at the site of tissue damage. Compositions and methods for inhibition of the expression and function of the LYST protein are described. The compositions and methods can be useful for the modulation of immune processes that contribute to formation of neointima and fibroproliferative disorders by altering macrophage, platelet and natural killer cell function to create a pro-regenerative immune response.
