A composition comprising first delayed release particles and second delayed release particles, the first and second delayed release particles comprising an effective amount of a narrow junction effector comprising a peptide comprising the amino acid sequence of SEQ ID No. 1, wherein the peptide is 8-15 amino acids in length, where the first delayed-release particles and the second delayed-release particles begin to release the peptide at different times in the intestinal fluid, and in which: First delayed release particles comprise: a first central particle； a first base coat on the first core particle, wherein the first coat comprises an effective amount of the peptide； and a first delayed-release coating outside the first basecoat, the first delayed-release coating being substantially stable in the gastric fluid and effectively releasing the peptide at a first time of release； and the second delayed release particles comprise: a second central particle； a second base coat on the second core particle, wherein the second base coat comprises the effective amount of the peptide； and a second delayed release coating, the second delayed release coating being substantially stable in the gastric fluid and effectively releasing the peptide in a second release time.Una composición que comprende unas primeras partículas de liberación retardada y unas segundas partículas de liberación retardada, comprendiendo las primeras y segundas partículas de liberación retardada una cantidad eficaz de un efector de la unión estrecha que comprende un péptido que comprende la secuencia de aminoácido de SEC ID Nº 1, en donde el péptido tiene una longitud de 8-15 aminoácidos, en donde las primeras partículas de liberación retardada y las segundas partículas de liberación retardada comienzan a liberar el péptido a diferentes tiempos en el fluido intestinal, y en la que: las primeras partículas de liberación retardada comprenden: una primera partícula central； un primer revestimiento de base s
