THE PRESENT INVENTION PROVIDES A CRYSTAL OF RECOMBINANT INTERFERON (RSIFN-CO). THE RECOMBINANT INTERFERON HAS (I) THE SAME AMINO ACID SEQUENCE AS THAT OF HUMAN CONSENSUS INTERFERON, AND (II) ALTERED THREE-DIMENSIONAL STRUCTURE AS COMPARED TO IFN-ALPHA2B. THE RECOMBINANT INTERFERON OF THE PRESENT INVENTION EXHIBITS ENHANCED BIOLOGICAL ACTIVITIES. THE PRESENT INVENTION ALSO PROVIDES A STRUCTURE MODEL OF THE RECOMBINANT INTERFERON WHICH CAN BE USED FOR DRUG SCREENING AND/OR DRUG DESIGN AND THE MIMETIC OF THE RECOMBINANT INTERFERON.
