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METHODS OF MODULATING CELLULAR HOMEOSTATIC PATHWAYS AND CELLULAR SURVIVAL
- 专利权人:
- Inc.;Dana-Farber Cancer Institute
- 发明人:
- Danial, Nika N.,Walensky, Loren D.,Bird, Gregory
- 申请号：
- AU2014202832
- 公开号：
- AU2014202832B2
- 申请日:
- 2014.05.23
- 申请国别(地区):
- AU
- 年份:
- 2016
- 代理人:
- 摘要：
- #$%^&*AU2014202832B220160128.pdf#####ABSTRACT The invention provides composition and therapeutic methods for modulating homeostatic pathways that are useful in treatment, and prevention of diabetes, diabetes associated disorders, metabolic disorders and cancer. See Figure 4.WO 2008/137633 PCT/US2008/062345 4/47 Glucose GK G6PO VE-1 PI OG6P Glucose PKA Glucose Metabolism t h* ' Insulin Secretion BH3 Domain BAD Active Multi-Domain BAX/BAK *.e Cytochromec Pro-apoptotics .Re *e* Release ~ID~ ~Mitchz dio.:t BCL-XL Apoptosome Effector MCL-2 Formation Caspases Multi-Domain Anti-apoptotics Fig. 4
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
