A method determining a retinal pigment epithelium identifies a plurality of regions using captured image data of the eye and fits a curve into at least some of the regions. A curve score is determined associated with the fitted curve using at least a distance between the fitted curve and at least some of the regions in which a contribution of the regions to the curve score is biased towards (asymmetric) regions below the fitted curve. These steps are repeated whereupon one of the fitted curves is selected, using the corresponding associated curve score, for classifying some of the regions as forming at least a part of a retinal pigment epithelium.
