BOURBEAU, MATTHEW P.,HARRINGTON, PAUL E.,LIU, QINGYIAN
申请号：
CA3047288
公开号：
CA3047288A1
申请日:
2017.12.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: (see Formula I structure) wherein variables R1, R1', R2, R2', R3, R4, R5, R6, R7, and b of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to Aß plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.
