This description provides mute u00ednas of hngal that Bind with a family member or pioquelina pyoverdin and can be used in various Applications including Pharmaceutical Applications, for example, to inhibit or reduce the growth of P. aeruginosa.This description also refers to methods for preparing one or more binding mute u00ednas pyoverdin or pioquelina described in this report, as well as to compositions comprising one or more such mute u00ednas.This description refers to Nucleic Acid molecules that encode these mute u00ednas and Methods for the generation of these mute u00ednas and Nucleic Acid molecules. In addition, describes the application and / or Diagnostic Therapeutic uses of these mute u00ednas and compositions comprising one or more such mute u00ednas.Claim 1: a polypeptide that has specificity Union for pyoverdin Type I, II, III or pioquelina, which comprises a mute u00edna polypeptide of hngal pyoverdin that binds to Type I, II, III or pioquelina with detectable Affinity.Claim 2: The polypeptide of claim 1, in which the rest of hngal mute u00edna comprises an amino acid mutation in one or more positions corresponding to the positions 28, 34, 36, 39, 42, 44, 47, 49, 52, 54, 55, 65, 68, 70, 72, 75, 77, 79, 81, 87, 97, 100, 103, 106, 108, 123, 125, 127, 132, 134, 141, 145 of the linear sequence of the mature polypeptide hngal (SEC ID no. 1).La presente descripción proporciona muteínas de hNGAL que se unen con un miembro de la familia de pioverdina o pioquelina y que pueden usarse en diversas aplicaciones incluyendo aplicaciones farmacéuticas, por ejemplo, para inhibir o reducir el crecimiento de P. aeruginosa. La presente descripción también se refiere a métodos para preparar una o más muteínas de unión a pioverdina o a pioquelina descritas en la presente memoria así como a composiciones que comprenden una o más de dichas muteínas. La presente descripción se refiere además a moléculas de ácido nucleico que codifican dichas muteínas y a métodos para la ge
