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Polymorphic forms of 1-′4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
专利权人:
Matthias Bartels;Andreas Bathe;Henning Böttcher;Bernd Helfert;Susanne Rudolph;Steffen Neuenfeld;Heike Kniel
发明人:
Andreas Bathe,Bernd Helfert,Steffen Neuenfeld,Heike Kniel,Matthias Bartels,Susanne Rudolph,Henning Böttcher
申请号:
US13085117
公开号:
US08318744B2
申请日:
2011.04.12
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.
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中国工程科技知识中心
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