THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
ITESCU, SILVIU
申请号：
CA2482996
公开号：
CA2482996C
申请日:
2003.04.23
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
This invention provides a method of treating a disorder of a subject's heartinvolving loss of cardiomyocytes which comprises administering to the subjectanamount of an agent effective to cause cardiomyocyte proliferation within thesubject's heart so as to thereby treat the disorder. This invention furtherprovidesthe instant method wherein the agent is human endothelial progenitor cells, G-CSF,GM-CSF, SDF-1, and IL-8. This invention also provides methods of determiningthe susceptibility of a cardiomyocyte in a subject to apoptosis. The inventionprovides methods of preventing cardiomyocyte apoptosis, reducing cardiacfibroblast proliferation, reducing myocardial scars and improving cardiacfunctionby inhibition of VDUP1 expression or function.
