Disclosed is the use of the compounds represented by formula (I) in the preparation of a medicament against tumor angiogenesis, wherein R1 and R2 are each independently C1-C8 alkylidene group or C2-C8 alkenylidene group A1 and A2 are each independently aryl, isoaryl, or aryl or isoaryl optionally substituted by halogen, -CN, -NO2, -OH, -SH, -OR3, -SR3, -R3, -R3-OR4, -C(O)R3, -S(O)R3, -S(O)2R3, -NR4R5, -C(O)OR3, -C(O)NR4R5, -O(O)CR4, -S(O)CR4 or -NR4(O)CR5, wherein R3 is C1-C4 alkyl, R4 and R5 are each independently hydrogen, C1-C4 alkyl, aryl or substituted aryl and X and Y are each independently oxygen and the compound of formula (I) does not include phenethyl caffeate.
