Methods for manufacturing a denture including providing a cavity having a plurality of wells formed therein for receiving denture teeth, inserting denture teeth into the wells so that distal coronal aspects face into the wells, positioning the cavity over a core to form a molding void therebetween, in which the exposed proximal aspects of the denture teeth are in the molding void, and introducing a molding material into the molding void to envelope the proximal aspects of the denture teeth and form a denture base upon at least partial setting of the molding material. Once set, the denture base with denture teeth retained therein may be removed from the cavity and core. Using such methods, a kit of differently sized prefabricated dentures in which the denture bases comprise a plastically deformable material may be provided, an appropriate denture selected, and semi-customized to a patient.