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다당류 유사-스폰지
专利权人:
发明人:
사토 토모야
申请号:
KR1020067004020
公开号:
KR1011359370000B1
申请日:
2004.09.10
申请国别(地区):
KR
年份:
2012
代理人:
摘要:
While maintaining a certain degree of strength is low swelling property provides an in vivo degradable high novel photo-crosslinked polysaccharide.Obtained as a crosslinking reaction of the photoreactive polysaccharide in the introduction of a photoreactive polysaccharide, low swelling properties described in the following (I) and (II) and blue dextran polysaccharide similar to that characterized by having a low staining properties - Sponge:(I) a solvent content of 96% by weight of test piece (thickness: 1mm, species: 10m, lateral: 10mm) to make and, swelling displayed to the test piece by the following formula of one or less measured after 1-hour-immersion in room temperature water for injection ratio this is less than 125%.Degree of swelling = {(S2-S1) / S1} X 100Among way,Sl is the area before immersion,S2 represents the area after immersion. At this time, the search area is calculated from the length of the longitudinal and transverse of the test piece.(Il) of the solvent content of 96% by weight of test piece (thickness: 1mm, species: 20mm, lateral: 10mm) and the after manufacture, is immersed in the specimen to 0.5g / mL aqueous solution of blue dextran having a weight average molecular weight of only 200, washed with water and it decomposes the specimen singer and preparing an aqueous solution of 0.67% by weight in terms of the polysaccharide concentration is not more than 0.15 optical density at a wavelength of 620nm measured with respect to the aqueous solution.Polysaccharide pseudo-sponge, a photoreactive group, the water-swellable, cross-linked, UV irradiation, medical materials어느 정도의 강도를 유지하면서 팽윤성이 낮고 생체내 분해성이 높은 신규한 광가교 다당류를 제공한다.다당류에 광반응성 기를 도입한 광반응성 다당류의 가교 반응으로 얻으며, 이하의 (I) 및 (II)에 기재된 저팽윤 특성 및 블루 덱스트란 저 염색 특성을 갖는 것을 특징으로 하는 다당류 유사-스폰지:(I) 용매 함유율 96 중량%의 시험편(두께: 1mm, 종:10m, 횡: 10mm)을 제조하고, 이 시험편을 주사용수에 실온에서 1시간 침지시킨 후에 측정한 이하의 식으로 표시되는 팽윤율이 125% 이하이다.팽윤율 = {(S2-S1)/S1} X 100식중에서,Sl은 침지 전의 면적이고,S2는 침지 후의 면적을 나타낸다. 이때, 면적은 시험편의 종과 횡의 길이로부터 산출됨.(Il) 용매
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