A transdermal therapeutic system including: a support layer of a flexible tape； an adhesive layer that is permeable and laminated in a surface of the support layer； a drug that is transdermally absorbable and stored in each of a plurality of storage cavities in the surface of at least the support layer among the support layer and the adhesive layer； and a liner layer detachably laminated in an adhesive surface of the adhesive layer, wherein when a polyether ether ketone resin film having low irritancy is used as the support layer, the polyether ether ketone resin film is used as a sample, and an intradermal reaction test is carried out by using an extract extracted under predetermined conditions in a physiological saline or sesame oil, a difference in average scores of an extract administration site and a blank extract administration site is 1.0 or less in any of extraction media.
