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New crystalline form III of agomelatine, a process for its preparation and pharmaceutical compositions containing it
专利权人:
LES LABORATOIRES SERVIER
发明人:
SOUVIE JEAN-CLAUDE,COQUEREL GÉRARD,LINOL JULIE
申请号:
NO20063516
公开号:
NO337010B1
申请日:
2006.08.02
申请国别(地区):
NO
年份:
2015
代理人:
摘要:
Crystalline form III of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide is new. The compound is confirmed by powder X-ray diffraction pattern as given in the specification. An independent claim is included for preparation of the crystalline form III of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide involves: heating agomelatine at 110[deg]C until fully melted, and then slowly cooled until recrystallization occurs. ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Gastrointestinal-Gen; CNS-Gen; Cardiovascular-Gen.; Neuroleptic; Muscular-Gen.; Immunomodulator; Eating-Disorder-Gen.; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Neuroprotective; Dermatological; Antimigraine; Cerebroprotective; Endocrine-Gen.; Cytostatic; Analgesic; Contraceptive. MECHANISM OF ACTION : Melatoninergic system receptor agonist; 5-HT(hydroxytryptamine)-2C receptor antagonist. No biological data given.Krystallinsk form III av forbindelsen med formel (l): karakterisert ved dens pulverrøntgendiffraksjonsdiagram. Medikamenter.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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