Paul Insel,Fiona Murray,Lingzhi Zhang,Trishna Katakia,Andrea Wilderman,Charles Gray
申请号：
US14782804
公开号：
US20160349261A1
申请日:
2014.04.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The disclosure provides diagnostic and therapeutic agents for chronic lymphocytic leukemia (CLL). Further provided are biomarkers and a biomarker panel comprising G-protein coupled receptors (GPCRs) specifically expressed by CLL cells. Methods for diagnosing a disease stage of a CLL patient, progression, or prediction of clinical course and drug selection for the CLL patient, as well as methods for treating CLL, by targeting these GPCR biomarkers are also provided.
