A biopsy apparatus includes a driver assembly and a disposable biopsy probe assembly for releasable attachment to the driver assembly. The driver assembly includes a first vacuum path having a first one-way valve configured and arranged to permit a negative pressure fluid flow toward a vacuum source and to prevent a positive pressure fluid flow away from the vacuum source. The disposable biopsy probe assembly includes a second vacuum path having a second one-way valve configured and arranged to permit the negative pressure fluid flow from a sample basket and to redundantly prevent the positive pressure fluid flow toward the sample basket. A fluid management tank is fluidically interposed in the second vacuum path between the first end and the second end. The fluid management tank includes a filter arrangement to prevent a flow of residual biopsy biological material from the sample basket to the vacuum source.
