#$%^&*AU2009202332B220120112.pdf#####USE OF AMINO-OXY FUNCTIONAL GROUPS IN THE PREPARATION OF VACCINES CONJUGATES Abstract 5 The invention relates to a process for preparing a conjugate comprising combining an amino-oxy homofunctional or heterofunctional reagent with an entity chosen from polysaccharides, oligosaccharides, carbohydrates, and carbohydrate-containing molecules containing at least one carbonyl group, to form a polysaccharide, oligosaccharide, 10 carbohydrate, or carbohydrate-containing molecule functionalized via at least one oxime linkage. The functionalized compound is then reacted either directly or indirectly with a protein molety to form a protein-carbohydrate conjugate that may be used as a vaccine.
