Vaccines comprising oligonucleotides having immunostimulatory sequences (ISS) wherein the ISS are conjugated to antigens and stabilized by buffer conditions and further excipients

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专利权人:

Dynavax Technologies Corporation

发明人:

Rodriguez, Roberto,Tuck, Stephen F.

申请号：

AU2006220835

公开号：

AU2006220835B2

申请日:

2006.03.03

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

The present invention provides compositions comprising conjugate molecules that are structurally stable at a temperature of between about 2 degrees C and 8 degrees C. In some examples, a conjugate molecule comprises an antigen, such as an allergen. In some examples, a conjugate molecule comprises the Ragweed antigen Amb a 1. The present invention provides methods for making and using such compositions. Provided herein are methods for modulating an immune response in an individual comprising administration of a composition comprising a structurally stable conjugate molecule as described herein.

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