A guide wire luer hub has an elongated hub body with a longitudinal lumenhaving aplurality of transitions between different lumen sections with differentdiameters and/or taperangles. The guide wire luer hub is adapted for use with a coaxial guide wiretubing extending froma catheter control handle, where the coaxial tubing has an outer cover ortubing coaxiallysurrounding a guide wire inner body with a lumen adapted to receive a guidewire, including aguide wire having a floppy, U-bend distal end.
