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Stable and soluble antibodies that inhibit TNF
专利权人:
ESBATech; an Alcon Biomedical Research Unit LLC
发明人:
BORRAS, Leonardo,GUNDE, Tea,URECH, David
申请号:
DK09768692
公开号:
DK2307457T3
申请日:
2009.06.25
申请国别(地区):
DK
年份:
2018
代理人:
摘要:
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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