KIM, Ik Soo,김익수,KIM, Han Gyu,김한규,HONG, Cheol Am,홍철암,LEE, Su Yeon,이수연
申请号：
KRKR2017/000272
公开号：
WO2018/021637A1
申请日:
2017.01.09
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
The present invention relates to a composition, which is for repairing rotator cuff tears and includes nucleic acid and chitosan. More specifically, a composition for repairing rotator cuff tears and prepared by mixing nucleic acid and chitosan was ascertained to undergo a temperature-dependent sol-gel transition and have a greater tissue-repairing effect than typical individual compositions, and it was ascertained that the rate of decomposition of the composition was slowed and the residence time of the composition in a tear region was increased such that the tissue-repairing effect was prolonged. Thus, it is expected that by using the composition of the present invention, which is for repairing rotator cuff tears and includes nucleic acid and chitosan, it will be possible to develop a therapeutic composition that is remarkably effective for repairing torn rotator cuff tissue.Linvention porte sur un composé destiné à réparer les déchirures de la coiffe des rotateurs, qui comprend de lacide nucléique et du chitosane, dont la transition de solide en gel, dépendamment de la température, a un meilleur effet de réparation des tissus que les composés individuelles typiques. Il a été déterminé que le taux de décomposition du composé a été ralenti et que son temps de séjour dans la région de la déchirure a été augmenté de sorte à prolonger leffet de réparation de tissus. Ainsi, on sattend à ce que, à laide du composé de la présente invention, destinée à réparer les déchirures de la coiffe des rotateurs, et qui comprend de lacide nucléique et du chitosane, il sera possible de développer un composé thérapeutique remarquablement efficace pour réparer le tissu déchiré de la coiffe des rotateurs.본 발명은 핵산 및 키토산을 포함하는 회전근개 파열 수복용 조성물에 관한 것으로, 보다 자세하게는 핵산 및 키토산의 혼합을 통해 제조된 회전근개 파열 수복용 조성물은 온도에 따라 졸-겔 전이가 일어나는 것을 확인하였고, 기존의 단일 조성물 보다 조직 수복 효과가 높고, 조성물의 분해 속도를 늦추고,파열 부위에서의 조성물의 체류 시간을 증가시킴으로써 조직 수복 효과가 지속되는 것을 확인하였다. 이를 통해, 본 발명의 핵산 및 키토산을 포함하는 회전근개 파열 수복용 조성물을 이용하여 파열된 회전근개 조직의 수복
