A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R 1 represents the formula -A 11 -A 12 R 2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl A 11 represents a single bond, methylene or 1,2-ethylene A 12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl R 3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl and R 4 represents methoxy or chlorine.
