LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME

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专利权人:

OPKO Biologics Ltd

发明人:

FIMA Udi Eyal,FIMA Udi Eyal,HART Gili,HART Gili

申请号：

SI201031374

公开号：

SI2451473T1

申请日:

2010.07.01

申请国别(地区):

SI

年份:

2017

代理人:

摘要：

A polypeptide consisting of a coagulation factor and one to five human chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said coagulation factor, wherein said coagulation factor is Factor VII or Factor VIIa, and wherein the sequence of said CTPs comprises the first 10 amino acids of SEQ ID NO: 4 (i.e., the amino acid sequence SSSSKAPPPS), and optionally, a signal peptide attached to the amino terminus of said coagulation factor. Pharmaceutical compositions comprising the polypeptides and medical uses thereof are also disclosed.

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