Eosinophilia Associated With Immune Deficiency

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作   者：

Olbrich, Peter;  Ortiz Aljaro, Pilar;  Freeman, Alexandra F.; 

作者机构：

Hosp Univ Virgen Rocio IBiS;  Lab Clin Immunol & Microbiol;  Virgen del Rocio University Hospital;  NIAID;  Hosp Univ Virgen Rocio;  US; 

关键词：

STAT3 MUTATIONS;  SEVERE COMBINED IMMUNODEFICIENCY;  IgE;  Immunodeficiency;  PHENOTYPE;  IL-5;  DOMINANT;  CLINICAL-FEATURES;  GLYCOSYLATION;  Inborn errors of immunity;  Eosinophilia;  INBORN-ERRORS;  HYPER-IGE SYNDROME;  Hyper-Ige;  ATOPY;  Eosinophils;  MANIFESTATIONS; 

期刊名称：

The journal of allergy and clinical immunology. In practice.

i s s n：

2213-2198

年卷期：

2022 年 10 卷 5 期

页   码：

1140-1154

页   码：

摘   要：

The differential diagnosis of eosinophilia is broad and includes infections, malignancies, and atopy as well as inborn errors of immunity (IEI). Certain types of IEIs are known to be associated with elevated numbers of eosinophils and frequently elevated serum IgE, whereas for others the degree and frequency of eosinophilia are less established. The molecular defects underlying IEI are heterogeneous and affect different pathways, which highlights the complex regulations of this cell population within the immune system. In this review, we list and discuss clinical manifestations and therapies of immune deficiency or immune dysregulation disorders associated with peripheral blood or tissue eosinophilia with or without raised IgE levels. We present illustrative case vignettes for the most common entities and propose a diagnostic algorithm aiming to help physicians systematically to evaluate patients with eosinophilia and suspicion of an underlying IEI. Published by Elsevier Inc.