Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition

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作   者：

Charlene Compher;  Angela L. Bingham;  Michele McCall;  Jayshil Patel;  Todd W. Rice;  Carol Braunschweig;  Liam McKeever; 

作者机构：

University of Pennsylvania;  Medical College of Wisconsin;  and Critical Care Medicine;  Pulmonary;  Vanderbilt University School of Medicine;  Division of Pulmonary and Critical Care Medicine;  Department of Kinesiology and Nutrition;  Cooper University Hospital;  St. Michael's Hospital;  School of Nursing;  Division of Allergy;  Division of Epidemiology and Biostatistics;  Department of Pharmacy;  Medical/Surgical Intensive Care Unit;  Biobehavioral Health Sciences Department;  University of; 

关键词：

enteral nutrition;  mechanical ventilation;  critical illness;  critical care;  lipid;  randomized controlled trial;  nutrition;  parenteral nutrition;  pneumonia;  guideline;  protein;  length of stay;  mortality;  intensive care unit;  adult;  nutrition support;  bacteremia;  energy; 

期刊名称：

JPEN. Journal of parenteral and enteral nutrition.

i s s n：

0148-6071

年卷期：

2022 年 46 卷 1 期

页   码：

12-41

页   码：

摘   要：

Abstract Background This guideline updates recommendations from the 2016 American Society for Parenteral and Enteral Nutrition (ASPEN)/Society of Critical Care Medicine (SCCM) critical care nutrition guideline for five foundational questions central to critical care nutrition support. Methods The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) process was used to develop and summarize evidence for clinical practice recommendations. Clinical outcomes were assessed for (1) higher vs lower energy dose, (2) higher vs lower protein dose, (3) exclusive isocaloric parenteral nutrition (PN) vs enteral nutrition (EN), (4) supplemental PN (SPN) plus EN vs EN alone, (5A) mixed‐oil lipid injectable emulsions (ILEs) vs soybean oil, and (5B) fish oil (FO)–containing ILE vs non‐FO ILE. To assess safety, weight‐based energy intake and protein were plotted against hospital mortality. Results Between January 1, 2001, and July 15, 2020, 2320 citations were identified and data were abstracted from 36 trials including 20,578 participants. Patients receiving FO had decreased pneumonia rates of uncertain clinical significance. Otherwise, there were no differences for any outcome in any question. Owing to a lack of certainty regarding harm, the energy prescription recommendation was decreased to 12–25 kcal/kg/day. Conclusion No differences in clinical outcomes were identified among numerous nutrition interventions, including higher energy or protein intake, isocaloric PN or EN, SPN, or different ILEs. As more consistent critical care nutrition support data become available, more precise recommendations will be possible. In the meantime, clinical judgment and close monitoring are needed. This paper was approved by the ASPEN Board of Directors.