Gene expression in subcutaneous adipose tissue differs in women with polycystic ovary syndrome and controls matched pair-wise for age, body weight, and body mass index

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作   者：

Louise Manneras-Holm;  Anna Benrick;  Elisabet Stener-Victorin; 

作者机构：

Institute of Neuroscience and Physiology;  University of Gothenburg;  Sweden;  Gothenburg;  Department of Physiology;  Sahlgrensl; 

关键词：

chemokine (C-C motif) ligand 2 (CCL2);  insulin sensitivity;  twist-related protein 1 (TWISTl);  PCOS;  lipoprotein lipase (LPL);  adiponectin receptor 2 (ADIPOR2);  adipose tissue;  heme oxygenase (decyciing 1) (HMOXl);  gene expression; 

期刊名称：

Adipocyte

i s s n：

2162-3945

年卷期：

2014 年 3 卷 3 期

页   码：

190-196

页   码：

摘   要：

Adipose tissue dysfunction may be a central factor in the pathogenesis of insulin resistance in women with polycystic ovary syndrome (PCOS). Gene expression in subcutaneous adipose tissue in PCOS and its relation to metabolic and endocrine features ofthe syndrome have been fragmentarily investigated. The aim was to assess in subcutaneous adipose tissue the expression of genes potentially associated with adipose tissue dysfunction and to explore their relation to features of the syndrome. Twenty-onewomen with PCOS (body mass index [BMI] 18.2-33.4 kg/m^) and 21 controls (BMI 19.2-31.7 kg/m^) were matched pair-wise for age, body weight, and BMI. Tissue biopsies were obtained to measure mRNA expression of 44 genes (TaqMan Low Density Array). Differential expression levels were correlated with BMI, glucose infusion rate (GIR), sex hormone binding globulin (SHBG), and sex steroids. In PCOS, expression of adiponectin receptor 2 (ADIP0R2), LPL, and twist-related protein 1 (TWIST!) was decreased, while expression of chemokine (C-C motif) ligand 2 (CC/.2) and heme oxygenase (decycling 1) {HMOXl) was increased. TWISTl and HMOXl, both novel adipokines, correlated with BMI and GIR. After BMI adjustment, LPL and ADIP0R2 expression correlated with plasma estradiol, and CCL2 expression correlated with GIR, in all women. We conclude that adipose tissue mRNA expression differed in PCOS women and controls and that two novel adipokines, TWISTl and HMOXl, together with adiponectin, LPL, and CCL2, and their downstream pathways merit further investigation.

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