Enantioselective Aza-Henry Reaction with Acyclic Guanidine- Thiourea Bifunctional Organocatalyst

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作   者：

Keisuke Takada;  Kazuo Nagasawa; 

作者机构：

2-24-16 Naka-cho;  Department of Biotechnology and Life Science;  Graduate School of Engineering;  Koganei;  Tokyo University of Agriculture and Technology (TUAT);  Japan;  Tokyo 184-8588; 

关键词：

organic catalysts;  aza-Henry reaction;  thioureas;  guanidines;  phase-transfer catalyst; 

期刊名称：

Advanced synthesis & catalysis

i s s n：

1615-4150

年卷期：

2009 年 351 卷 3 期

页   码：

345-347

页   码：

摘   要：

A highly enantioselective aza-Henry reaction of imines with nitromethane was achieved with a reactive guanidine-thiourea bifunctional organocatalyst affording β-nitroamines with high enantio-selectivity (up to 96% ee). The diastereo- and enantioselective version of this reaction with nitroal-kanes also proceeded selectively (up to 99:1 dr with 99% ee).