1. 研究金属和有机小分子催化的环加成及环化反应，特别是基于1,3-偶极子的高效、高选择性环加成反应， 发展高效的选择性合成方法，并利用手性金属催化剂和手性有机小分子催化剂发展高效和高选择性的不对 称合成新方法，研究这些方法在杂环分子及复杂生物活性分子合成中的应用。 2. 合成具有重要生物活性的杂环化合物及天然产物，用于杀虫剂、除草剂、杀菌剂及植物生长调节剂等的研 究，开展新农药创制工作。 3. 结合有机化学、生物化学和分子生物学，利用小分子探针研究植物中重要蛋白质的结构和作用

研究方向

应用化学

所在机构

名称：中国农业大学理学院应用化学系 邮编：100193 地址：北京市圆明园西路2号

主要成就

已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Rev., Chem. Commun., Chem. Eur. J., Adv. Synth. Catal., J. Org. Chem., Tetrahedron, Tetrahedron Lett., Synlett, Synthesis等刊物上发表70余篇论文，总被引1000余次，参与编写5本专著，授权2项专利。2011年入选教育部新世纪优秀人才计划。 Honglei Liu, Yang Wu, Yan Zhao, Zhen Li, Lei Zhang, Wenjun Yang, Hui Jiang, Chengfeng Jing, Hao Yu, Bo Wang, Yumei Xiao, Hongchao Guo,* “Metal-Catalyzed [6+3] Cycloaddition of Tropone with Azomethine Ylides: A Practical Access to Piperidine-Fused Bicyclic Heterocycles”, J. Am. Chem. Soc. 2014, 136, 2625–2629. Zhen Li, Hao Yu, Honglei Liu, Lei Zhang, Hui Jiang, Bo Wang, and Hongchao Guo,* “Phosphine-Catalyzed [3+2] Cycloaddition Reactions of Azomethine Imines with Electron-Deficient Alkenes: A Facile Access to Dinitrogen-Fused Heterocycles”, Chem. Eur. J. 2014, 20, 1731–1736. Zhilin Yang, Hao Yu, Lei Zhang, Hang Wei, Yumei Xiao, Lanzhen Chen, Hongchao Guo,* “PPh3-Catalyzed Ring-Expansion Reactions of Sulfamate-Derived Cyclic Imines with Acetylenedicarboxylates”, Chem. Asian J. 2014, 9, 313–318 Zhenzhen Gao, Lei Zhang, Zhanhu Sun, Hao Yu, Yumei Xiao,* and Hongchao Guo,* “DABCO-catalyzed [3 + 2] Annulation of Sulfamate-derived Cyclic Imines with Isocyanoacetates: Synthesis of Sulfamate-fused 2-Imidazoline”, Org. Biomol. Chem. 2014, 12, accepted. Yumei Xiao, Zhanhu Sun, Hongchao Guo,* and Ohyun Kwon,* “Chiral Phosphines in Nucleophilic Organocatalysis”, Beilstein J. Org. Chem. 2014, accepted. Hao Yu, Lei Zhang, Zhen Li, Honglei Liu, Bo Wang, Yumei Xiao, Hongchao Guo,* “Phosphine-catalyzed [4+2] cycloaddition of sulfamate-derived cyclic imines with allenoates: synthesis of sulfamate-fused tetrahydropyridines”, Tetrahedron 2014, 70, 340–348. Zhen Li, Hao Yu, Lei Zhang, Honglei Liu, Risong Na, Qinghua Bian,* Min Wang,* Hongchao Guo,* “Thermal [3+2] cycloaddition reaction of N-?acyliminophenanthridinium betaine with allenoates: Facile access to phenanthridine-?fused tetracyclic heterocycles”, Lett. Org. Chem. 2014, 11, 220–224. Lei Zhang, Hao Yu, Zhilin Yang, Honglei Liu, Zhen Li, Junhong Guo, Yumei Xiao, Hongchao Guo,* “Phosphine-catalyzed [3+2] cycloaddition of Morita-Baylis-Hillman carbonates with sulfamate-derived cyclic imines”, Org. Biomol. Chem. 2013, 11, 8235–8240. Hao Yu, Lei Zhang, Zhilin Yang, Zhen Li, Yan Zhao, Yumei Xiao, Hongchao Guo,* “Phosphine-Catalyzed [3+2] Cycloaddition of Sulfamate-Derived Cyclic Imines with Allenoate: Synthesis of Sulfamate-Fused Dihydropyrroles”, J. Org. Chem. 2013, 78, 8427–8436. Hongchao Guo,* Honglei Liu, Fu-Lin Zhu, Risong Na, Hui Jiang, Yang Wu, Lei Zhang,Zhen Li, Hao Yu, Bo Wang, Yumei Xiao, Xiang-Ping Hu,* Min Wang, “Enantioselective Copper-Catalyzed [3+3] Cycloaddition of Azomethine Ylides with Azomethine Imines”, Angew. Chem. Int. Ed. 2013, 52, 12641–12645. Lei Zhang, Chengfeng Jing, Honglei Liu, Bo Wang, Zhen Li, Hui Jiang, Hao Yu, Hongchao Guo*, “Thermal [3+2] Cycloaddition of Aromatic Azomethine Imines with Allenoates”, Synthesis 2013, 45, 53–64. Changkui Fu, Chongyu Zhu, Shiqi Wang, Honglei Liu, Yun Zhang, Hongchao Guo, Lei Tao*, Yen Wei*, “One-pot synthesis of optically active polymer via concurrent cooperation of enzymatic resolution and living radical polymerization”, Polym. Chem. 2013, 4, 264–267. Yang Wu, Hongchao Guo,* “Synthesis of allenoates”, Chemical Reagents 2013, 35, 1085–1088. Risong Na, Bo Wang, Honglei Liu, Qinghua Bian, Jiangchun Zhong, Min Wang* and Hongchao Guo*, “Synthesis and Application of Novel Dithiane Alcohol Ligand Based on Chiral Cyclopropane-backbone for Asymmetric Ethylation of Aromatic Aldehydes”, Lett. Org. Chem. 2012, 9, 622–627. Hui Jiang, Risong Na, Lei Zhang, Honglei Liu, Zhen Li, Bo Wang, Hongchao Guo*, “Samarium Diiodide Mediated Highly Diastereoselective Conjugate Reduction of the alpha,beta-Unsaturated Ester Moiety in Heterocyclic Compounds”, Synthesis 2012, 44, 3633–3638. Chengfeng Jing, Risong Na, Honglei Liu, Lei Zhang, Jun Liu, Min Wang, Jiangchun Zhong,* Ohyun Kwon, and Hongchao Guo*, “Phosphine-catalyzed [3+2] and [4+3] Annulation Reactions of C,N-Cyclic Azomethine Imines with Allenoates”, Adv. Synth. Catal. 2012, 354, 1023–1034. Risong Na, Zhen Li, Honglei Liu, Jun Liu, Ming-An Wang, Min Wang, Jiangchun Zhong and Hongchao Guo,* “Thermal [3+2] Cycloaddition Reaction of Azomethine Imines with Allenoates for Dinitrogen-fused Heterocycles”, Tetrahedron 2012, 68, 2349–2356. Jun Liu, Honglei Liu, Risong Na, Guiyong Wang, Min Wang, Jiangchun Zhong* and Hongchao Guo,* “Phosphine-Catalyzed [3+2] and [3+3] Annulations of Azomethine Imines with Ethyl 2-Butynoate”, Chem. Lett. 2012, 41, 218–230. Xi Wu, Risong Na, Honglei Liu, Jun Liu, Min Wang, Jiangchun Zhong,* Hongchao Guo,* “Sequential [3+2] Cycloaddition/Rearrangement Reaction of Imidazolone Nitrones and Allenoates for the Efficient Synthesis of Functionalized Imidazolidinone”, Tetrahedron Lett.2012, 53, 342–344. Hongchao Guo, Kuiling Ding,* “Self-Supported Chiral Catalysts for Heterogeneous Asymmetric Catalysis”, Chimia 2011, 65, 932–938. Risong Na, Chengfeng Jing, Qihai Xu, Hui Jiang, Xi Wu, Jiayan Shi, Jiangchun Zhong, Min Wang, Diego Benitez, Ekaterina Tkatchouk, William A. Goddard, III, Hongchao Guo,* Ohyun Kwon,* “Phosphine-Catalyzed Annulations of Azomethine Imines: Allene-Dependent [3+2], [3+3], [4+3], and [3+2+3] Pathways”, J. Am. Chem. Soc. 2011, 133, 13337–13348. Bing Zheng, Min Wang, Zhiyuan Li, Qinghua Bian, Jianyou Mao, Shuoning Li, Shangzhong Liu, Mingan Wang, Jiangchun Zhong,* Hongchao Guo,* “Asymmetric Henry reaction catalyzed by a Zn–amino alcohol system”, Tetrahedron: Asymmetry 2011, 22, 1156–1160. Jing Nie, Hongchao Guo, Dominique Cahard, Jun-An Ma,* “Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates”, Chem. Rev. 2011, 111, 455–529. Zhiyuan Li, Min Wang, Qinghua Bian, Bing Zheng, Jianyou Mao, Shuoning Li, Shangzhong Liu, Ming-an Wang, Jiangchun Zhong,* Hongchao Guo,* “Highly Enantioselective Addition of Trimethylsilylacetylene to Aldehydes Catalyzed by a Zinc-Amino-Alcohol Complex”, Chem. Eur. J. 2011, 17, 5782–5786. Hongchao Guo, Kuiling Ding, “Indium Tribromide”, Encyclopedia of Reagents for Organic Synthesis, 2011. Hongchao Guo, Kuiling Ding, “Self-Supported Chiral Catalysts”, In Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications, First Edition. Michelangelo Gruttadauria, Franceso Giacalone, Eds., John Wiley & Sons, Inc. 2011, Chapter 5, p.257–290. Hongchao Guo, Qihai Xu, Ohyun Kwon,* “Phosphine-Promoted [3+3] Annulation of Aziridines with Allenoates: A Facile Entry into Highly Functionalized Tetrahydropyridines”, J. Am. Chem. Soc. 2009, 131, 6318–6319. This article was selected by the Editorial Board of Synfacts for its important insights, Synfacts 2009, 748, was also highlighted by Chemtracts, Chemtracts-Organic Chemistry 2010, 23, 111–114. Manfred T. Reetz*, Hongchao Guo, Jun-An Ma, Richard Goddard, Richard J. Mynott, “Helical Triskelion Monophosphites as Ligands in Asymmetric Catalysis”, J. Am. Chem. Soc. 2009, 131, 4136–4142. Bing Zheng, Shicong Hou, Zhiyuan Li, Hongchao Guo, Jiangchun Zhong*, Min Wang*, “Enantioselective synthesis of quaternary stereogenic centers through catalytic asymmetric addition of dimethylzinc to alpha-ketoesters with chiral cis-cyclopropane-based amide alcohol as ligand”, Tetrahedron: Asymmetry 2009, 20, 2125–2129. Hongchao Guo, Kuiling Ding,* “New Advance in Combinatorial Asymmetric Catalysis”, In New Concepts and Methods in Asymmetric Catalysis”, K. L. Ding, Q. H. Fan, Eds., Chemical Industry Press, Beijing, 2009, Chapter 14, p.431–463.

教育背景

1993-1997 中国农业大学应用化学系, 理学学士 1997-2002 中国农业大学应用化学系, 理学博士